[Research Progress in Detection of Malignant Hematologic Diseases by Bio-electrochemistry -Review]

Hematologic disease has become a common disease that produces harm and burdens to human individuals today, seriously threatening public health care. Particularly, the damage caused by malignant hematologic disease has been recognized by doctors and patients. However, low cure rate and high recurrence rate are the main issues when treating malignant hematologic disease by current methods. The survival rate could be significantly improved if the early metaphase diagnosis rate could be improved. Therefore, early diagnosis is important for malignant hematologic disease at molecular level. In recent years, the bio-electrochemical method for tumor cells and blood detection has attracted more and more attention. Because many cancer cell surface proteins are important biomarkers, changing in the surface proteins'quantity and condition as well as a variety of electrophysiological activity often show some potential diseases. Each cancer cell has a specific biomarker to distinguish it from the normal cell line. As a result, their biomarkers can be detected by bioelectrochemical techniques. Therefore, it provides theoretical and experimental support for detecting the cancer cell activity, diagnosis and treatment of diseases, and screening the drugs. In recent years, the development of biosensor, nanotechnology, probe and electrode, as well as Lab-on-a-chip has contributed a lot to the development of bioelectrochemistry, especially the development of the inspection and drug resistance in hematological and oncological diseases. This review lists the different composition of bio-electrochemical technology, focusing on the progress in hematologic field so as to put forward the research.