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Murine Prostate Micro-dissection and Surgical Castration
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Testosterone and the Prostate.

Ronny B W Tan1, Jonathan L Silberstein2, Wayne J G Hellstrom3

  • 1Department of Urology, Tan Tock Seng Hospital, Novena, Singapore.

Sexual Medicine Reviews
|October 1, 2014
PubMed
Summary
This summary is machine-generated.

Testosterone replacement therapy (TRT) is safe for aging men with prostate issues. Current evidence suggests TRT does not worsen lower urinary tract symptoms (LUTS) or increase prostate cancer risk.

Keywords:
Androgen ReceptorsBrachytherapyExternal Beam RadiotherapyLate‐Onset HypogonadismProstate CancerRadical ProstatectomySaturation ModelTestosterone Deficiency SyndromeTestosterone Replacement Therapy

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Area of Science:

  • Andrology
  • Urology
  • Oncology

Background:

  • Late-onset hypogonadism, lower urinary tract symptoms (LUTS) from benign prostatic enlargement (BPE), and prostate cancer frequently coexist in aging men.
  • Understanding of testosterone's physiological role in prostate health has evolved, altering perspectives on testosterone replacement therapy (TRT).

Approach:

  • A comprehensive literature review was conducted.
  • The review focused on TRT's effects on benign prostatic growth and prostate cancer.
  • Evidence regarding TRT for men with BPE and prostate cancer was evaluated.

Key Points:

  • TRT does not appear to exacerbate LUTS.
  • Current evidence suggests TRT may not elevate the risk of a subsequent prostate cancer diagnosis.
  • TRT is unlikely to impact recurrence or progression in men with treated prostate cancer, though further research is needed.

Conclusions:

  • TRT is not contraindicated in men with BPE.
  • TRT is not contraindicated in men with effectively treated prostate cancer.