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Testosterone Therapy for Female Sexual Dysfunction.

Mohit Khera1

  • 1Baylor College of Medicine, Houston, TX, USA.

Sexual Medicine Reviews
|July 1, 2015
PubMed
Summary
This summary is machine-generated.

Testosterone therapy (TTh) is a safe and effective treatment for female sexual dysfunction (FSD), improving desire, arousal, and satisfaction. While side effects like acne can occur, TTh does not appear to increase cancer risk.

Keywords:
Androgen DeficiencyAndrogensFemale Sexual DysfunctionTestosterone

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Area of Science:

  • Reproductive Medicine
  • Endocrinology
  • Sexual Health

Background:

  • Female sexual dysfunction (FSD) affects a significant portion of the female population, with prevalence estimates ranging from 9% to over 50%.
  • Testosterone therapy (TTh) is increasingly utilized for FSD treatment, despite its off-label status in the United States and lack of FDA approval for this indication.
  • Understanding the efficacy and safety of TTh is crucial for managing FSD.

Approach:

  • A comprehensive literature review was conducted using PubMed, searching for studies on female sexual dysfunction, testosterone, and androgens up to 2014.
  • Expert opinion was synthesized from relevant scientific and medical literature.
  • The assessment focused on peer-reviewed literature detailing TTh for FSD, including diagnosis, treatment options, and adverse effects.

Key Points:

  • Testosterone therapy has demonstrated improvements in key aspects of female sexual function, including sexual desire, arousal, pleasure, and overall satisfaction.
  • Potential adverse effects of TTh, such as acne and hirsutism, have been noted.
  • Current evidence does not support a link between TTh and an increased risk of cancers, including breast and endometrial cancer.

Conclusions:

  • Testosterone therapy is considered a safe and effective treatment option for improving symptoms of female sexual dysfunction.
  • Further research may be warranted to fully elucidate long-term safety and efficacy profiles.