Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

25.4K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
25.4K
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

678
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
678
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.1K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.1K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

1.7K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
1.7K
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

875
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
875
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.3K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Unfinished Business of Defining Premature Ejaculation: The Need for Targeted Research.

Sexual medicine reviews·2022
Same author

Disorders of Ejaculation: An AUA/SMSNA Guideline.

The Journal of urology·2021
Same author

Advances and Missteps in Diagnosing Premature Ejaculation: Analysis and Future Directions.

The journal of sexual medicine·2021
Same author

Response to Letter to the Editor Regarding "Cligosiban for Premature Ejaculation: Success, Failure, or Insufficiently Tested?"

The journal of sexual medicine·2019
Same author

Pharmacokinetics, Clinical Efficacy, Safety Profile, and Patient-Reported Outcomes in Patients Receiving Subcutaneous Testosterone Pellets 900 mg for Treatment of Symptoms Associated With Androgen Deficiency.

The journal of sexual medicine·2017
Same author

Changes in the Effects of Peyronie's Disease After Treatment With Collagenase Clostridium histolyticum: Male Patients and Their Female Partners.

Sexual medicine·2017

Related Experiment Video

Updated: Mar 13, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.2K

Current and Emerging Treatments for Premature Ejaculation.

Chris G McMahon1

  • 1Australian Centre for Sexual Health, Sydney, NSW, Australia.

Sexual Medicine Reviews
|July 1, 2015
PubMed
Summary
This summary is machine-generated.

Selective serotonin reuptake inhibitors (SSRIs) are effective first-line treatments for premature ejaculation (PE). While daily SSRIs offer superior results, on-demand options may suit some patients seeking PE pharmacotherapy.

Keywords:
DapoxetineOxytocinPremature EjaculationSelective Serotonin Reuptake InhibitorsTramadolα1-Adrenoceptor Antagonists

More Related Videos

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

5.1K
Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation
03:19

Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation

Published on: August 30, 2024

1.4K

Related Experiment Videos

Last Updated: Mar 13, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.2K
Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

5.1K
Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation
03:19

Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation

Published on: August 30, 2024

1.4K

Area of Science:

  • Pharmacology and Urology
  • Sexual Medicine
  • Neuroscience of Ejaculation

Background:

  • The treatment of premature ejaculation (PE) has evolved from psychotherapy to pharmacotherapy over the last 20-30 years.
  • Current pharmacotherapy targets neurotransmitters like serotonin, dopamine, oxytocin, norepinephrine, GABA, and nitric oxide (NO) involved in ejaculation control.

Approach:

  • A review and critique of contemporary data on PE treatment using evidence-based medicine principles.
  • Evaluation of integrated pharmacotherapy and cognitive behavioral therapy (CBT) for superior outcomes.
  • Assessment of phosphodiesterase type 5 inhibitors (alone or with SSRIs) for acquired PE secondary to erectile dysfunction (ED).

Key Points:

  • Selective serotonin reuptake inhibitors (SSRIs) are proven safe and effective for delaying ejaculation in lifelong and acquired PE.
  • Daily SSRI dosing demonstrates superior increases in intravaginal ejaculation latency time compared to on-demand SSRIs.
  • On-demand SSRIs are less effective but can meet the treatment goals for certain patients with PE.

Conclusions:

  • Psychosexual CBT has a limited role in current PE management.
  • Dapoxetine, off-label SSRIs, and topical anesthetics are effective and safe for PE.
  • Tramadol and α1-adrenoceptor antagonists require further large-scale trials before recommendation for PE treatment.