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Endodermal Sinus Tumor Presented With Ascites: A Case Report.

Ahmet Cumhur Dulger1, Huseyin Begenik2, Ramazan Esen2

  • 1Yuzuncu Yil University, Medical faculty, Gastroenterology, Van, Turkey.

Gastroenterology Research
|June 1, 2012
PubMed
Summary

This case study details a rare primary endodermal sinus tumor (EST) of the omentum in a young male. Despite BEP chemotherapy, the patient succumbed to the aggressive extragonadal neoplasm.

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Endodermal sinus tumor (EST) is a rare germ cell neoplasm, typically originating in the gonads (testis or ovary).
  • Extragonadal EST, particularly within the abdomen, represents an exceptionally rare clinical presentation.

Observation:

  • A 19-year-old male presented with ascites, a rare manifestation of primary omental endodermal sinus tumor.
  • Ascitic fluid analysis revealed elevated alpha-fetoprotein (AFP) and CA 125 levels.
  • Laparoscopic biopsy confirmed the diagnosis of endodermal sinus tumor.

Findings:

  • The patient received four cycles of the BEP regimen (bleomycin, etoposide, cisplatin) for treatment.
  • Despite aggressive chemotherapy, the patient's condition rapidly deteriorated, leading to death two months post-presentation.
Keywords:
Endodermal sinus tumorLow gradient ascites

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Implications:

  • This case highlights the extreme rarity of primary omental endodermal sinus tumors.
  • Clinicians should consider extragonadal EST in young patients presenting with ascites and elevated tumor markers (AFP, CA 125), even with a low ascitic fluid gradient.