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Gastrointestinal Motility Monitor GIMM
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Curcumin Relaxes Precontracted Guinea Pig Gallbladder Strips via Multiple Signaling Pathways.

Loren W Kline1, Edward Karpinski2

  • 1School of Dentistry, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

Gastroenterology Research
|October 28, 2016
PubMed
Summary
This summary is machine-generated.

Curcumin, from turmeric, relaxes gallbladder smooth muscle by affecting protein kinase C (PKC) and calcium channels. This study investigated curcumin

Keywords:
Calcium channelsCurcuminGallbladderPotassium channelsSmooth muscle

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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Molecular Biology

Background:

  • Curcumin, the active compound in turmeric, is known to modulate various signaling molecules.
  • It influences inflammatory agents, transcription factors, protein kinases, and cell cycle regulatory proteins.

Purpose of the Study:

  • To investigate the effect of curcumin on gallbladder motility.
  • To determine the specific signaling pathways involved in curcumin-induced gallbladder relaxation.

Main Methods:

  • An in vitro pharmacologic technique using guinea pig gallbladder strips was employed.
  • Concentration-dependent relaxation responses to curcumin were measured.
  • Second messenger systems were investigated using specific inhibitors and agents like tetraethylammonium chloride (TEA).

Main Results:

  • Curcumin demonstrated a concentration-dependent relaxation of gallbladder strips.
  • Protein kinase A (PKA) did not appear to mediate the relaxation.
  • Inhibition of protein kinase C (PKC) and blocking of extracellular calcium (Ca2+) entry significantly reduced curcumin-induced relaxation.
  • Tetraethylammonium chloride (TEA) also significantly decreased relaxation, indicating involvement of K+ channels.

Conclusions:

  • Curcumin-induced gallbladder relaxation is mediated by multiple signaling pathways.
  • These pathways include the protein kinase C (PKC) system.
  • Inhibition of extracellular calcium (Ca2+) entry and modulation of potassium (K+) channels are also involved in curcumin's effect on gallbladder motility.