Related Experiment Video
Updated: Mar 13, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
HDL as a Causal Factor in Atherosclerosis: Insights from Human Genetics
Liam R Brunham1,2,3
1Department of Medicine, University of British Columbia, Vancouver, Canada. Liam.brunham@ubc.ca.
Abstract:
High-density lipoprotein cholesterol (HDL-C) levels are inversely related to risk of atherosclerotic cardiovascular disease (ASCVD). However, the simplistic assumption that HDL-C levels directly and causally impact atherogenesis has been challenged in recent years. The purpose of this article is to review the current state of knowledge regarding genetically determined HDL-C levels and ASCVD risk and determine what insight these studies provide into the causal relationship between HDL and atherosclerosis.
Related Concept Videos
Coronary Artery Disease I: Introduction
Atherosclerosis I: Introduction
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Atherosclerosis III: Management
Pharmacogenomics: Identification of New Drug Targets
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...

