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Related Experiment Video

Updated: Mar 13, 2026

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

Default mode network deactivation during odor-visual association.

Prasanna R Karunanayaka¹, Donald A Wilson^2,3, Michael J Tobia¹

¹Department of Radiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Human Brain Mapping

|October 28, 2016

Summary

This summary is machine-generated.

The default mode network (DMN) deactivates during olfactory tasks, showing its crucial role in processing smells and guiding responses. This brain network interacts significantly with the olfactory system during scent perception.

Keywords:

default mode network (DMN)fMRI olfaction

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Area of Science:

Neuroscience
Cognitive Neuroscience
Sensory Processing

Background:

The default mode network (DMN) is known for its role in internally directed thought and is typically deactivated during goal-directed cognitive tasks.
Understanding the DMN's function in sensory processing, particularly olfaction, is crucial for a comprehensive view of brain activity.

Purpose of the Study:

To investigate the role of the default mode network (DMN) during olfactory processing.
To examine the interplay between the DMN and the olfactory network using functional magnetic resonance imaging (fMRI).

Main Methods:

Employed two complementary fMRI paradigms: an odor-visual association task and a control no-odor task.
Utilized Independent Component Analysis (ICA), extended unified structural equation modeling (euSEM), and psychophysiological interaction (PPI) to analyze brain connectivity.
Investigated DMN deactivation patterns in response to olfactory and visual stimuli in 29 healthy adults.

Main Results:

DMN deactivation was observed in response to both odor+visual and visual-only trials in the odor-visual association paradigm.
Visual-only trials in the absence of odor did not consistently evoke DMN deactivation.
euSEM and PPI analyses revealed significant directed connectivity between the DMN and olfactory network, differing between trial conditions.

Conclusions:

The findings support a strong interaction between the default mode network and the olfactory network.
The DMN plays a significant role in task-evoked brain activity and behavioral responses during olfactory processing.