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Updated: Mar 13, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Squamous cell carcinoma arising from a vulval epidermal cyst
Shirley Sze1, Ian Richmond2, Adam Bickers3
1Department of Obstetrics and Gynaecology, Diana, Princess of Wales Hospital, Grimsby, Lincolnshire, UK. shirley.sze@nhs.net.
Abstract:
Malignant transformation of epidermal cyst is rare, with most cases arising in the head and neck. Here, we report a case of squamous cell carcinoma arising from a longstanding epidermal cyst in the right vulva of a 65-year-old woman. The patient presented with a sudden increase in size of the cyst over 6 weeks to the size of a golf ball. Excisional biopsy and histology indicated moderately differentiated squamous cell carcinoma within an epidermal cyst (FIGO stage IB). Strong p16 immunopositivity was also demonstrated and the potential significance of this is discussed. Limited right hemivulvectomy and right groin node dissection were performed.
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