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Published on: October 18, 2019
Can the composition of the intestinal microbiota predict the development of urinary tract infections?
Casper Dj den Heijer1, Suzanne E Geerlings2, Jan M Prins2
1Department of Medical Microbiology, Maastricht University Medical Centre/Care & Public Health Research Institute (CAPHRI), Maastricht, The Netherlands.
Aim:
To evaluate whether intestinal microbiota predicts the development of new-onset urinary tract infections (UTIs) in postmenopausal women with prior recurrent UTIs (rUTIs).
Patients & Methods:
Fecal samples (n = 40) originated from women with rUTI who received 12 months' prophylaxis of either trimethoprim-sulfamethoxazole (TMP-SMX) or lactobacilli. Microbial composition was assessed by 16S rRNA pyrosequencing.
Results:
At baseline, fecal microbiota of women with zero and more than or equal to four UTIs during follow-up showed no significant differences. Only TMP-SMX prophylaxis resulted in reduced microbial diversity. Microbial structure of two samples from the same woman showed limited relatedness.
Conclusion:
In postmenopausal women with rUTI, the intestinal microbiota was not predictive for new-onset UTIs. Only TMP-SMX, and not lactobacilli, prophylaxis had effects on the microbial composition. Data in ENA:PRJEB13868.
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