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Anticholinergic medication use is associated with globus pharyngeus
S Haft1, R M Carey1, D Farquhar1
1Department of Otorhinolaryngology: Head and Neck Surgery,University of Pennsylvania,Philadelphia,USA.
The Journal of Laryngology and Otology
|October 28, 2016
Summary
Anticholinergic medications and gastroesophageal reflux disease significantly increase the odds of experiencing globus pharyngeus. Awareness of these risk factors is crucial for effective globus treatment.
Area of Science:
- Otolaryngology
- Pharmacology
- Gastroenterology
Background:
- Globus pharyngeus is often associated with salivary hypofunction.
- Anticholinergic medication use may contribute to globus sensation through a drying effect.
- This study investigates the link between anticholinergic medications and globus pharyngeus.
Purpose of the Study:
- To determine the association between anticholinergic medication use and globus sensation.
- To identify risk factors contributing to globus pharyngeus.
Main Methods:
- A cross-sectional study of 270 patients in a laryngology practice.
- Patients rated globus sensation severity; those with a score of 0 were controls.
- Multivariate analysis compared globus scores with medication lists, comorbidities, age, and gender (p < 0.05).
Main Results:
- Taking at least two anticholinergic medications increased the odds of experiencing globus by 3.52 (p = 0.02).
- Gastroesophageal reflux disease was significantly associated with globus, with an odds ratio of 3.75 (p = 0.004).
Conclusions:
- A significant portion of idiopathic globus cases may be linked to anticholinergic use or reflux.
- Medication use is implicated as a risk factor for globus pharyngeus.
- Understanding these associations aids in diagnosing and treating globus.
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