Psychiatric distress in animals versus animal models of psychiatric distress
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Updated: Mar 13, 2026

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
Published on: July 15, 2025
1Departments of Biological Sciences, Neurology and Neurosurgery, Stanford University, Stanford, California, USA and the Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya.
Abstract:
The realm of human uniqueness steadily shrinks; reflecting this, other primates suffer from states closer to depression or anxiety than 'depressive-like' or 'anxiety-like behavior'. Nonetheless, there remain psychiatric domains unique to humans. Appreciating these continuities and discontinuities must inform the choice of neurobiological approach used in studying any animal model of psychiatric disorders. More fundamentally, the continuities reveal how aspects of psychiatric malaise run deeper than our species' history.

