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In vitro sodium salicylate release from a sucrose polyester matrix
P M Castellano1, M A Pastoriza, M Martińez de Bertorello
1Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Abstract:
Sucrogel H-70, a recently synthesized polyester of sucrose, was investigated as a potential drug delivery matrix. In this study, the release of sodium salicylate was examined from a reservoir-controlled release device. It is shown that sodium salicylate release follows zero-order kinetics in the three media studied (i.e., water and simulated gastric and intestinal fluids).
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