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Serum irisin levels in patients with psoriasis
Anna Baran1, Hanna Myśliwiec1, Paulina Kiluk1
1a Department of Dermatology and Venereology , Medical University of Bialystok , Bialystok , Poland.
The Journal of Dermatological Treatment
|October 28, 2016
Summary
Irisin levels in psoriasis patients did not significantly differ from controls and showed no link to disease severity or metabolic issues. However, irisin correlated with inflammation markers like CRP, suggesting a role in psoriatic inflammation.
Area of Science:
- Endocrinology
- Dermatology
- Metabolic Research
Background:
- Irisin is implicated in metabolic regulation, relevant to comorbidities in psoriasis.
- Psoriasis is frequently associated with metabolic disorders like obesity and diabetes.
Purpose of the Study:
- To assess serum irisin levels in psoriasis patients.
- To explore associations between irisin and disease activity, inflammation, metabolic parameters, and treatment response.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) measured serum irisin in 37 psoriasis patients and 15 controls.
- Correlations were analyzed with Psoriasis Area and Severity Index (PASI), BMI, inflammatory markers (CRP), and lipid profiles.
- Measurements were taken before and after two weeks of topical treatment.
Main Results:
- Serum irisin levels were not significantly different between psoriatic patients and controls.
- No significant correlations were found between irisin and metabolic parameters, BMI, or PASI.
- Irisin showed significant positive correlations with C-reactive protein (CRP), lipocalin-2, age, and disease duration.
Conclusions:
- Irisin may serve as an inflammation marker in psoriasis.
- Irisin is unlikely to be a reliable indicator of metabolic status, psoriasis severity, or treatment efficacy.
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