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Capsular opacification associated with silicone implants.

J R Shepherd

    Journal of Cataract and Refractive Surgery
    |July 1, 1989
    PubMed
    Summary
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    This study found that sulcus-fixated silicone intraocular lenses led to more posterior capsule opacification compared to bag-fixated lenses. Bag-fixated silicone lenses showed the lowest incidence, suggesting fixation location is key.

    Area of Science:

    • Ophthalmology
    • Biomaterials Science

    Background:

    • Posterior capsular opacification (PCO) is a common complication after cataract surgery.
    • The choice of intraocular lens (IOL) material and fixation location may influence PCO development.

    Purpose of the Study:

    • To compare the incidence of significant posterior capsular opacification (PCO) within 12 months post-surgery.
    • To evaluate the impact of IOL material (silicone vs. poly(methyl methacrylate)) and fixation (sulcus vs. bag) on PCO.

    Main Methods:

    • Prospective comparison of three IOL groups: sulcus-fixated silicone, bag-fixated poly(methyl methacrylate) (PMMA), and bag-fixated silicone.
    • Standardized surgical technique performed by a single surgeon.
    • Assessment of PCO incidence via capsulotomy rates at 12 months post-operatively.

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    Main Results:

    • The incidence of capsulotomy was 16.5% for sulcus-fixated silicone lenses.
    • Bag-fixated PMMA lenses had a capsulotomy incidence of 7.9%.
    • Bag-fixated silicone lenses demonstrated the lowest capsulotomy incidence at 4.8%.

    Conclusions:

    • Sulcus-fixated silicone IOLs are associated with a higher rate of early PCO.
    • The low PCO rate with bag-fixated silicone lenses suggests that fixation location, not silicone material itself, is the primary factor influencing PCO.
    • Bag fixation of silicone IOLs appears to be a safe and effective strategy to minimize PCO.