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An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
What is the effect of pill burden on adherence to HIV antiretroviral therapy?
S Scott Sutton1, Divya Ahuja, Joseph Magagnoli
1S. Scott Sutton is a professor in the Department of Clinical Pharmacy and Outcomes Sciences in the South Carolina College of Pharmacy at the University of South Carolina in Columbia, S.C. Divya Ahuja is an associate professor in the University of South Carolina School of Medicine. Joseph Magagnoli is a statistician in the Dorn Research Institute at the Veterans Affairs Medical Center in Columbia, S.C. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Antiretroviral therapy (ART) is a combination treatment involving three or more antiretroviral agents for patients with HIV. ART has reduced HIV-related morbidity and mortality via single-tablet or multiple-tablet regimens. Single-tablet regimens, with their lower pill burdens, have demonstrated higher adherence rates, improved viral suppression, and reduced resource use compared with multiple-tablet regimens. In addition, select newer ARTs do not require the high levels of adherence for viral load suppression required by older ART formulations.
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