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Basophil Activation Test for Allergy Diagnosis
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[Insect venom allergies : Update 2016 for otorhinolaryngologists]
L Klimek1,2, N Dippold3, A Sperl3
1Zentrum für Rhinologie und Allergologie, An den Quellen 10, 65183, Wiesbaden, Deutschland. ludger.klimek@Allergiezentrum.org.
HNO
|October 28, 2016
Summary
Hymenoptera venom allergies are increasing. Molecular diagnostics and rush allergen-specific immunotherapy (AIT) improve diagnosis and treatment for these potentially life-threatening insect sting allergies.
Area of Science:
- Allergy and Immunology
- Otolaryngology
Background:
- Hymenoptera venom allergies are rising, posing significant health risks.
- Otolaryngologists require updated knowledge on diagnosing and treating these allergies.
Purpose of the Study:
- To outline modern diagnostic and treatment standards for Hymenoptera venom allergies.
- To emphasize the role of molecular diagnostics and specific immunotherapy.
Main Methods:
- Utilizing molecular diagnostics with recombinant allergens for precise diagnosis.
- Evaluating patient history and diagnostic tests to guide treatment.
- Assessing the indication for allergen-specific immunotherapy (AIT).
Main Results:
- Molecular diagnostics improve accuracy, especially in cases with ambiguous extract-based tests.
- Distinguishes between true dual sensitization and cross-reactivity to bee or wasp venom.
- Rush AIT shows particular effectiveness as an initial treatment strategy.
Conclusions:
- Modern diagnostics, including molecular testing, are crucial for accurate Hymenoptera venom allergy management.
- Allergen-specific immunotherapy (AIT), particularly rapid desensitization, offers an effective treatment approach.
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