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Characterizing Semaphorin-Mediated Immune Responses Using an Antigen-Presentation Assay
Satoshi Nojima1,2,3, Atsushi Kumanogoh4,5,6
1Division of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Abstract:
Semaphorins, which were originally identified as axon-guidance molecules, also serve multiple functions in various phases of immune responses. In particular, several semaphorins regulate antigen presentation by dendritic cells (DCs) and resultant differentiation of CD4+ T cells. Here we describe a method for investigating both functions in vitro. This method might be used to obtain insight into novel aspects of semaphorin-mediated immunity.
