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A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Loay Awad1, Nino Jejelava2, Ritwik Burai2
1College of Engineering, University of Dammam, P. O. Box 1982, Dammam, 31451, Saudi Arabia.
Chembiochem : a European Journal of Chemical Biology
|October 28, 2016
Abstract:
We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and β-sheet formation of amyloidogenic peptides.

