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Peripheral adenosine levels in euthymic patients with bipolar disorder
Carolina Gubert1, Cesar Eduardo Jacintho Moritz2, Mirela Paiva Vasconcelos-Moreno3
1Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil.
Psychiatry Research
|October 28, 2016
Summary
Bipolar disorder patients show lower serum adenosine levels, linked to increased depression and functional impairment. This suggests an adenosinergic dysfunction may contribute to the disorder
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Purinergic signaling is implicated in bipolar disorder pathophysiology.
- Adenosine, a key purine, plays roles in neurotransmission and mood regulation.
Purpose of the Study:
- To investigate serum adenosine levels in bipolar disorder patients.
- To examine the relationship between adenosine levels and clinical functioning in bipolar disorder.
Main Methods:
- Serum adenosine levels were measured using high-pressure liquid chromatography.
- Functioning was assessed with the Functioning Assessment Short Test.
- 24 euthymic bipolar I disorder patients and 25 healthy controls were studied.
Main Results:
- Bipolar disorder patients exhibited significantly lower serum adenosine levels compared to controls.
- Adenosine levels negatively correlated with depression scale scores in patients.
- Lower adenosine levels were associated with greater functional impairment in bipolar disorder.
Conclusions:
- Evidence suggests a purinergic imbalance, specifically adenosinergic dysfunction, in bipolar disorder.
- Adenosine levels may be related to the severity of functional impairment and depressive symptoms.
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