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Complete Genome Sequence Analysis of Echovirus 18 Associated with Aseptic Meningitis in Hebei Province, China, in

Xiang-Peng Chen1, Su-Zhen Sun2, Jia-Yun Guo1

  • 1Key Laboratory of Major Diseases in Children, Ministry of Education, National Key Discipline of Pediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Genome Announcements
|October 30, 2016
PubMed

Insights

Researchers sequenced the complete genome of Echovirus 18, a virus causing meningitis in children. This finding aids in understanding enterovirus infections and developing diagnostic tools for aseptic meningitis.

Area of Science:

  • Virology
  • Molecular Biology
  • Infectious Diseases

Background:

  • Echovirus 18 belongs to the Enterovirus genus within the Picornaviridae family.
  • Enteroviruses are a common cause of viral meningitis, particularly in pediatric populations.
  • Aseptic meningitis can lead to serious neurological complications if not properly identified.

Purpose of the Study:

  • To determine the complete genome sequence of an Echovirus 18 strain.
  • To provide genetic data for Echovirus 18 isolated in China.
  • To contribute to the genomic surveillance of enteroviruses.

Main Methods:

  • Viral RNA extraction from cerebrospinal fluid.
  • Next-generation sequencing for whole-genome amplification and sequencing.
  • Bioinformatic analysis for genome assembly and characterization.

Main Results:

  • The complete genome sequence of Echovirus 18 was successfully obtained.
  • Sequence analysis provided insights into the genetic makeup of this specific viral isolate.
  • The isolate originated from a child diagnosed with aseptic meningitis in Hebei Province, China.

Conclusions:

  • The availability of the Echovirus 18 complete genome sequence enhances our understanding of viral diversity.
  • This genomic data can support the development of specific diagnostic assays for Echovirus 18.
  • Further research can utilize this sequence for epidemiological and evolutionary studies of enteroviruses.

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