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Updated: Mar 13, 2026

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Published on: July 15, 2014

Cryofibrinogenaemia-a neglected disease.

Sergey Moiseev^1,2, Raashid Luqmani³, Pavel Novikov¹

¹Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University.

Rheumatology (Oxford, England)

|October 30, 2016

Summary

Cryofibrinogenemia (CF) involves abnormal plasma protein precipitation. While often asymptomatic, CF can cause severe skin issues and thrombosis, necessitating further research into its diagnosis and treatment.

Keywords:

cryofibrinogenaemia vasculitis vasculopathy

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Area of Science:

Hematology
Clinical Pathology

Background:

Cryofibrinogenemia (CF) is characterized by abnormal plasma protein precipitation.
CF is found in healthy individuals and patients with autoimmune diseases, cancer, and infections.

Purpose of the Study:

To review the clinical significance, diagnosis, and management of cryofibrinogenemia.
To highlight the challenges in diagnosing and treating symptomatic CF.

Main Methods:

Literature review of studies on cryofibrinogenemia.
Analysis of case reports and uncontrolled series on treatment efficacy.

Main Results:

Essential CF is often asymptomatic but can lead to significant complications like skin ulcers, gangrene, and thrombotic events.
Diagnosing CF can be challenging due to a lack of established criteria.
Treatment options for symptomatic CF lack robust evidence, with management often relying on addressing underlying conditions for secondary CF.

Conclusions:

The clinical importance and prevalence of CF are likely underestimated.
Further research is needed to establish diagnostic criteria and effective treatment strategies for cryofibrinogenemia.