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Vitamin D, calcium homeostasis and aging
Vaishali Veldurthy1, Ran Wei1, Leyla Oz1
1Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.
Bone Research
|October 30, 2016
Summary
Calcium deficiency and aging contribute to osteoporosis by disrupting calcium balance, often due to inadequate vitamin D levels. Understanding vitamin D
Area of Science:
- Gerontology and Endocrinology: Focuses on aging-related hormonal changes and bone health.
Background:
- Osteoporosis is defined by low bone mass and deteriorating bone microarchitecture, increasing fracture risk.
- Aging is linked to impaired calcium balance, with calcium deficiency playing a significant role.
- Vitamin D is crucial for maintaining calcium homeostasis, but elderly individuals often have insufficient levels.
Approach:
- This article reviews current knowledge on vitamin D metabolism and its role in calcium homeostasis.
- It examines age-related changes in the action of 1,25(OH)2D3 (calcitriol).
- The review covers recommended vitamin D and calcium intake and discusses the controversial use of vitamin D analogs for osteoporosis.
Key Points:
- Inadequate vitamin D levels in the elderly contribute to disturbed calcium balance and osteoporosis risk.
- Age-related dysregulation of vitamin D action impacts calcium homeostasis.
- Optimal vitamin D and calcium intake is essential for bone health.
Conclusions:
- Further research into vitamin D's molecular pathways and age-related modifications is needed.
- Understanding these mechanisms may lead to novel therapeutic strategies for maintaining calcium balance and preventing osteoporosis.
- The role of vitamin D analogs in osteoporosis treatment requires further investigation.
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