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Association of Vitamin D Deficiency with Coronary Artery Disease
Deba Prasad Dhibar1, Yash Paul Sharma2, Sanjay Kumar Bhadada3
1Senior Resident, Department of Internal Medicine, PGIMER , Chandigarh, India .
Insights
Vitamin D deficiency is highly prevalent in patients with Coronary Artery Disease (CAD). However, this study found no significant correlation between low vitamin D levels and the severity of CAD.
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- Coronary Artery Disease (CAD) is a significant global health concern.
- Low vitamin D levels (<30ng/ml) have been linked to hypertension and CAD, potentially via endothelial damage, though findings are inconsistent.
Purpose of the Study:
- To investigate the association between vitamin D deficiency and Coronary Artery Disease.
- To explore potential correlations between vitamin D levels and the angiographic severity of CAD.
Main Methods:
- A cross-sectional observational study involving 315 patients undergoing coronary angiography.
- Serum vitamin D levels were measured and analyzed in relation to CAD presence and severity.
Main Results:
- The mean serum vitamin D level was 13.40ng/ml (±10.40), with a high prevalence of deficiency across all CAD groups.
- No statistically significant correlation was found between vitamin D levels and the degree of coronary artery stenosis (p=0.46) or the number of diseased vessels (p=0.14).
Conclusions:
- Vitamin D deficiency is common in patients with Coronary Artery Disease.
- The study did not find a correlation between vitamin D deficiency and the angiographic severity of CAD.
Introduction:
Coronary Artery Disease (CAD) is a major global health problem. Recent studies demonstrated that lower vitamin D level (<30ng/ml) is associated with higher blood pressure and directly or indirectly with CAD, due to vascular endothelial damage. However the results are inconsistent.
Aim:
To find the association of vitamin D deficiency with CAD.
Materials And Methods:
In this cross-sectional observational study, serum vitamin D level was measured in 315 patients who underwent coronary angiography.
Result:
The mean (±SD) vitamin D was 13.40ng/ml (±10.40). However, the patients with normal coronary artery had much lower mean vitamin D (11.30ng/ml±9.50) as compared to the patients with CAD (14.10ng/ml±10.70). The mean (±SD) vitamin D levels were 19.00ng/ml (±16.50), 14.10ng/ml (±11.10) and 13.20ng/ml (±8.80) in patients with CAD with 50%-70%, >70%-90% and >90% stenosis respectively (p= 0.46) and 15.20ng/ml (±13.00), 15.50ng/ml (±11.30) and 11.80ng/ml (±7.00) in patients with CAD with single, double and triple vessels disease respectively (p= 0.14). The frequency of vitamin D deficiency were 66.70%, 83.20 % and 83.10% in patients with CAD with 50% -70%, >70%-90% and >90% stenosis respectively and 81.40%, 80.00% and 83.50% in patients with single, double and triple vessel disease respectively, as compared to 89.30% in patients with normal coronary artery (p= 0.41 and 0.075). So, all the study groups of CAD had low serum vitamin D level and high frequency of vitamin D deficiency, which was statistically insignificant.
Conclusion:
Prevalence of vitamin D deficiency is very high in CAD, but it does not correlate with the angiographic severity of CAD.
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