Related Experiment Video
Updated: Mar 13, 2026

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue
Published on: May 25, 2021
Unexplained Persistent Hyperglycaemia in a Type I Diabetes Patient - Is Injection Site Lipohypertrophy the Cause?
Ranjana Ajit Sahasrabudhe1, Tejas Yashwant Limaye2, Vidya Sanjay Gokhale3
1Associate Professor, Department of Pharmacology, BVDU Medical College , Pune, Maharashtra, India; Coordinator Medical Education Unit (Additional Charge) - Research Fellow, Diabetes Unit, KEM Hospitals, Pune, Maharashtra, India .
Abstract:
Type I diabetes patients depend on insulin injections. Proper injection technique is essential for good glycaemic control. Incorrect technique can also lead to local injection site adverse effects, commonest being lipohypertrophy. Hypoglycaemia, by far the most dreaded adverse effect of insulin, receives utmost focus in management of patients on insulin. Lipohypertrophy, on the other hand, is a relatively neglected adverse effect. It is necessary for health care providers to realize that it can also have serious clinical implications. We present a case of persistent unexplained hyperglycaemia in a Type I Diabetes Mellitus (TIDM) patient with severe injection site lipohypertropy. After switching to normal unused sites, her blood sugar levels improved, along with reduction in insulin requirement. The case highlights the importance of continuous patient education and alert monitoring by health care providers.
Related Concept Videos
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Type 2 and Gestational
Hypoglycemia and Glucagon
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...

