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Updated: Mar 13, 2026

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
Published on: November 22, 2024
Platelet activating factor: A potential biomarker in acute coronary syndrome?
Anand Vijaya Kumar Palur Ramakrishnan1, Treesa P Varghese1, Sreedevi Vanapalli1
1Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India.
Abstract:
Platelet activating factor (PAF) is a potent pro-inflammatory negotiator that shows distinct spectrum of biological and pharmacological effects. Importantly, it participates in a wide range of pathophysiological conditions. In cardiovascular system, PAF has been shown to have an important role in platelet and neutrophil aggregation, vascular permeability, microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells, and initiation and progression of atherosclerosis. The purpose of this article was to review the PAF, a family of lipids that is associated with the pathology of coronary artery diseases due to their association with leading etiological mechanisms such as inflammation, endothelial dysfunction, oxidative and nitrosative stress, and platelet reactivity. This review further provides information about PAF and its potential role as a key contributor to the pathogenesis of cardiovascular disorders.
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