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[Detection of concomitant pathology in patients with arterial hypertension by structural and functional changes of
Insights
Membrane tests assessing sodium-lithium countertransport and antibody binding can identify combined kidney disease in hypertension patients, aiding surgical effectiveness predictions.
Area of Science:
- Biochemistry
- Nephrology
- Cardiology
Context:
- Arterial hypertension (AH) management requires identifying combined pathologies.
- Erythrocyte membrane tests offer potential diagnostic insights.
- Assessing surgery effectiveness is crucial for patient outcomes.
Purpose:
- To compare Na-Li+ countertransport rate and monoclonal antibody binding in AH patients.
- To identify combined pathologies and predict surgical outcomes.
- To evaluate the utility of membrane tests in symptomatic renal genesis AH.
Summary:
- Na-Li+ countertransport rate and monoclonal antibody binding were measured in 27 AH patients.
- Membrane tests identified 3 patients with combined chronic pyelonephritis or glomerulonephritis.
- These tests supplement each other in assessing surgery effectiveness and identifying combined pathology.
Impact:
- Membrane tests can aid in diagnosing combined renal pathology in AH patients.
- This diagnostic approach may improve the prediction of surgical effectiveness.
- The findings contribute to a better understanding of symptomatic AH of renal genesis.
Abstract:
The values of the Na-Li+ countertransport rate and the degree of monoclonal antibody binding with the erythrocyte membranes were compared in patients with different forms of arterial hypertension (AH) to identify combined pathology and the precursors of surgery effectiveness. Among the 27 examined AH patients 7 underwent surgery in accordance with the initial clinical diagnosis. The membrane tests helped to detect 3 patients with combined pathology: chronic pyelonephritis or chronic diffuse glomerulonephritis in combination with AH. Thus, the membrane tests were found to supplement each other in the assessment of surgery effectiveness and the perspectives for identification of combined pathology in patients with symptomatic AH of renal genesis.