Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Histologic Entry Criteria for Clinical Trials in Celiac Disease Involving Gluten Challenge.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Celiac Disease.

The New England journal of medicine·2026
Same author

Small intestinal microbial fiber metabolism dysfunction in celiac disease.

Nature communications·2026
Same author

Evaluating the Clinical Relevance of Elevated Mucosal Mast Cells in the Gastrointestinal Tract.

Journal of clinical gastroenterology·2025
Same author

Drugs in Development and Clinical Trials for Celiac Disease.

Gastrointestinal endoscopy clinics of North America·2025
Same author

Immunology in Celiac Disease.

Gastrointestinal endoscopy clinics of North America·2025

Related Experiment Video

Updated: Mar 12, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

41.8K

Animal models to study non-celiac gluten sensitivity.

Plaimein Amnuaycheewa1, Joseph A Murray2,3, Eric V Marietta4,3,5

  • 1Department of Agro-Industrial, Food, and Environmental Technology, King Mongkut's University of Technology North Bangkok (KMUTNB), Bangkok, Thailand.

Minerva Gastroenterologica E Dietologica
|October 30, 2016
PubMed
Summary

Non-celiac gluten sensitivity (NCGS) is a complex condition with many unknowns. Animal models offer a promising avenue to explore wheat and gluten

More Related Videos

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
07:39

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

2.0K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K

Related Experiment Videos

Last Updated: Mar 12, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

41.8K
Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
07:39

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

2.0K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K

Area of Science:

  • Gastroenterology and Immunology
  • Wheat and Gluten-Related Disorders

Background:

  • Non-celiac gluten sensitivity (NCGS) is increasingly recognized, with a surge in publications and gluten-free diet adoption.
  • Despite growing interest, the pathophysiology, diagnostic criteria, and definition of NCGS remain unclear.
  • NCGS likely represents a heterogeneous group of disorders unified by a response to a gluten-free diet.

Purpose of the Study:

  • To review the utility of animal models in understanding non-celiac gluten sensitivity.
  • To explore how animal models can help elucidate the biological effects of wheat and gluten proteins.
  • To assess the potential of animal models for developing prevention and treatment strategies for NCGS.

Main Methods:

  • Review of existing literature on animal models relevant to NCGS.
  • Analysis of how animal models can isolate wheat and gluten components.
  • Focus on reducing confounding factors like human behavior and placebo effects.

Main Results:

  • Animal models allow for controlled investigation of wheat and gluten components.
  • They can help differentiate specific biological effects from other factors.
  • This approach aids in understanding the heterogeneity of NCGS.

Conclusions:

  • Animal models are valuable tools for advancing the understanding of NCGS.
  • They provide a pathway to investigate the specific roles of wheat and gluten proteins.
  • Further research using animal models may lead to improved diagnostics and therapeutics for NCGS.