Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography
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Updated: Mar 12, 2026

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
Published on: June 30, 2016
Hyeonseung Yu1, Peter Lee2, YoungJu Jo1
1Korea Advanced Institute of Science and Technology, Department of Physics, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreabKAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
Abstract:
We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and the wavefront shaping of illumination light controls multiple scattering, resulting in an enhancement of the penetration depth and signal-to-noise ratio. A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging. The penetration depth enhancement is further demonstrated for
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