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Published on: August 4, 2021
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Maternal genetic polymorphisms and unexplained recurrent miscarriage: a systematic review and meta-analysis
1Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Clinical Genetics
|October 30, 2016
Summary
Genetic polymorphisms are linked to recurrent miscarriage (RM) pathogenesis. This systematic review identified 53 genetic polymorphisms across 37 genes associated with RM, suggesting potential biomarkers for diagnosis and understanding disease mechanisms.
Area of Science:
- Genetics
- Reproductive Medicine
- Immunology
Background:
- Recurrent miscarriage (RM) pathogenesis is complex, with genetic factors playing a significant role.
- Previous studies on genetic polymorphisms in RM have yielded inconsistent results across different populations.
Purpose of the Study:
- To systematically review and meta-analyze genetic polymorphisms associated with recurrent miscarriage.
- To identify potential genetic biomarkers for RM.
Main Methods:
- Systematic literature search of PubMed, Medline, Embase, and CNKI databases.
- Meta-analysis of 369 articles evaluating 124 polymorphisms in 73 genes.
- Statistical analysis using odds ratios (ORs) and 95% confidence intervals (CIs), with p < 0.05 considered significant.
Main Results:
- A total of 425 eligible articles were included in the systematic review.
- Significant associations were found between RM and 53 genetic polymorphisms in 37 genes.
- Specific genes like HLA-G, IFNG, TNF, IL-6, IL-10, FII, FV, FXIII, ITGB3, MTR, MTHFR, PAI-1, NOS3, KDR, TP53, VEGFA, CYP17, CYP1A1, CYP2D6, ANXA5, and XCI were identified as potential biomarkers.
Conclusions:
- Genetic variants in immune response, coagulation, placental function, and metabolic regulation pathways are implicated in RM pathogenesis.
- Identified genetic polymorphisms may serve as valuable biomarkers for recurrent miscarriage.
- Further research can elucidate the precise mechanisms linking these genetic variants to RM.
