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Glycan-protein interactions in viral pathogenesis.

Rahul Raman1, Kannan Tharakaraman1, V Sasisekharan1

  • 1Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States.

Current Opinion in Structural Biology
|October 30, 2016
PubMed
Summary
This summary is machine-generated.

Complex glycans on host cells and viruses mediate viral interactions. Targeting these glycan-protein interactions offers new antiviral therapies and vaccines.

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Area of Science:

  • Glycobiology
  • Virology
  • Immunology

Background:

  • Host cell and viral surfaces feature complex glycans crucial for viral pathogenesis.
  • Glycans mediate viral entry, immune evasion, and protein processing through interactions with glycan-binding proteins (GBPs).

Purpose of the Study:

  • To review the multifaceted roles of glycan-GBP interactions in viral pathogenesis.
  • To explore the potential of targeting these interactions for antiviral therapeutic and vaccine development.

Main Methods:

  • Literature review of glycan synthesis, structural characterization, and interaction analysis.
  • Analysis of host cell surface glycans and viral surface glycans in disease.

Main Results:

  • Glycan-GBP interactions are central to viral-host dynamics, influencing multiple stages of the viral life cycle.
  • Advances in analytical tools provide deep insights into these interactions.

Conclusions:

  • Understanding glycan-GBP interactions is key to developing novel antiviral strategies.
  • Targeting these specific molecular interactions presents promising avenues for new treatments and vaccines.