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Updated: Oct 9, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
A narrative review of alcohol consumption as a risk factor for global burden of disease
Jürgen Rehm1,2,3,4,5,6, Sameer Imtiaz7,8
1Institute for Mental Health Policy Research, CAMH, 33 Russell Street, T505, Toronto, ON, M5S 2S1, Canada. jtrehm@gmail.com.
Abstract:
Since the original Comparative Risk Assessment (CRA) for alcohol consumption as part of the Global Burden of Disease Study for 1990, there had been regular updates of CRAs for alcohol from the World Health Organization and/or the Institute for Health Metrics and Evaluation. These studies have become more and more refined with respect to establishing causality between dimensions of alcohol consumption and different disease and mortality (cause of death) outcomes, refining risk relations, and improving the methodology for estimating exposure and alcohol-attributable burden. The present review will give an overview on the main results of the CRAs with respect to alcohol consumption as a risk factor, sketch out new trends and developments, and draw implications for future research and policy.
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