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Intestinal Barrier and Behavior.
1Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de, Valparaíso, Chile.
International Review of Neurobiology
|October 30, 2016
Summary
A compromised intestinal barrier may lead to systemic inflammation and impact central nervous system (CNS) function. Research explores the link between increased gut permeability and altered behavioral responses, suggesting a potential connection to CNS disorders.
Area of Science:
- Gastroenterology
- Neuroscience
- Immunology
Background:
- The intestinal barrier maintains gut homeostasis by regulating nutrient absorption and preventing pathogen entry.
- Intestinal barrier dysfunction is linked to chronic inflammatory conditions like rheumatoid arthritis, inflammatory bowel disease, and celiac disease.
Purpose of the Study:
- To explore the hypothesis that increased intestinal permeability contributes to systemic inflammation.
- To review current evidence on the association between gut permeability and central nervous system (CNS) disorders.
- To discuss the potential role of gut barrier disruption in altered behavioral responses.
Main Methods:
- Literature review of recent studies investigating gut permeability and CNS disorders.
- Analysis of evidence linking intestinal barrier function to systemic inflammation.
- Examination of data on the relationship between gut permeability and behavioral changes.
Main Results:
- Evidence suggests a correlation between increased gut permeability and systemic inflammation.
- Emerging research indicates a connection between gut permeability and CNS disorders.
- Studies are exploring whether gut barrier disruption is a cause or effect in these conditions.
Conclusions:
- A 'leaky gut' may facilitate the passage of intraluminal compounds, potentially triggering systemic inflammation.
- The translocation of intestinal contents could influence CNS function, impacting behavior.
- Further research is needed to elucidate the causal relationship between intestinal barrier integrity and CNS health.
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