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Intestinal Barrier and Behavior.

M Julio-Pieper1, J A Bravo1

  • 1Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de, Valparaíso, Chile.

International Review of Neurobiology
|October 30, 2016
PubMed
Summary
This summary is machine-generated.

A compromised intestinal barrier may lead to systemic inflammation and impact central nervous system (CNS) function. Research explores the link between increased gut permeability and altered behavioral responses, suggesting a potential connection to CNS disorders.

Keywords:
BehaviorGut–brain axisIntestinal permeability

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Area of Science:

  • Gastroenterology
  • Neuroscience
  • Immunology

Background:

  • The intestinal barrier maintains gut homeostasis by regulating nutrient absorption and preventing pathogen entry.
  • Intestinal barrier dysfunction is linked to chronic inflammatory conditions like rheumatoid arthritis, inflammatory bowel disease, and celiac disease.

Purpose of the Study:

  • To explore the hypothesis that increased intestinal permeability contributes to systemic inflammation.
  • To review current evidence on the association between gut permeability and central nervous system (CNS) disorders.
  • To discuss the potential role of gut barrier disruption in altered behavioral responses.

Main Methods:

  • Literature review of recent studies investigating gut permeability and CNS disorders.
  • Analysis of evidence linking intestinal barrier function to systemic inflammation.
  • Examination of data on the relationship between gut permeability and behavioral changes.

Main Results:

  • Evidence suggests a correlation between increased gut permeability and systemic inflammation.
  • Emerging research indicates a connection between gut permeability and CNS disorders.
  • Studies are exploring whether gut barrier disruption is a cause or effect in these conditions.

Conclusions:

  • A 'leaky gut' may facilitate the passage of intraluminal compounds, potentially triggering systemic inflammation.
  • The translocation of intestinal contents could influence CNS function, impacting behavior.
  • Further research is needed to elucidate the causal relationship between intestinal barrier integrity and CNS health.