Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A first in disease trial of the safety, tolerability, and anti-seizure effects of ES-481 in drug-resistant epilepsy.

Epilepsia open·2026

Same author

StatLI: A novel statistical approach to the laterality index for task-based fMRI.

Journal of neuroscience methods·2026

Same author

Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.

medRxiv : the preprint server for health sciences·2026

Same author

MRI techniques for detecting focal cortical dysplasia: A systematic review.

Seizure·2026

Same author

Assessment of language and executive functions in ALS: the brief executive Language screen.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026

Same author

Beneficial Effects of Intravenous Immunoglobulin Treatment in a Mouse Preclinical Model of Severe Traumatic Brain Injury.

Journal of neurotrauma·2025

Same journal

Prevalence and modulation of rat off-track head scanning on linear tracks: possible implications for representational and dynamic properties of hippocampal place cells.

Neuropsychologia·2026

Same journal

Identifying networks within an fMRI multivariate searchlight analysis.

Neuropsychologia·2026

Same journal

Modulating sentence comprehension in people with aphasia through anodal tDCS: A double-blind randomized cross-over study.

Neuropsychologia·2026

Same journal

Deficient processing of regularity violations during visuospatial neglect: a visual mismatch negativity study.

Neuropsychologia·2026

Same journal

Seeing is believing: mental imagery amplifies moral, emotional, and motivational responding to mentally constructed hypothetical events.

Neuropsychologia·2026

Same journal

From past recall to future projection: What does verb tense production reveal about mental time travel in Alzheimer's disease?

Neuropsychologia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 12, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Mentalizing in schizophrenia: A multivariate functional MRI study.

Andrew K Martin¹, Ilvana Dzafic², Gail A Robinson³

¹University of Queensland, Centre for Clinical Research, Brisbane, Qld, Australia; University of Queensland, Queensland Brain Institute, Brisbane, Qld, Australia.

Neuropsychologia

|November 7, 2016

Summary

This summary is machine-generated.

Schizophrenia patients show impaired mentalizing due to inefficient social brain networks. Functional connectivity differences in the left inferior frontal gyrus and caudate nucleus were observed during social cognition tasks.

Keywords:

Caudate nucleus Functional connectivity Inferior frontal gyrus Mentalizing Partial Least Squares Schizophrenia Superior temporal gyrus Theory of mind fMRI

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Related Experiment Videos

Last Updated: Mar 12, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Schizophrenia is linked to mentalizing deficits, affecting social function and quality of life.
Neural dysconnectivity is a recent conceptualization of schizophrenia, with network analyses aiding understanding of mentalizing difficulties.

Purpose of the Study:

To investigate neural network differences in mentalizing between schizophrenia patients and healthy controls using functional magnetic resonance imaging (fMRI).
To explore the relationship between brain connectivity, task performance, and mentalizing abilities in schizophrenia.

Main Methods:

Utilized The Triangles Task, an established mentalizing task, with fMRI data from 19 schizophrenia patients and 17 healthy controls (HCs).
Employed task-based Partial Least Squares (PLS) for activation analysis and seed-based PLS for functional connectivity assessment.
Conducted behavioral PLS using accuracy data from mentalizing conditions.

Main Results:

Schizophrenia patients exhibited poorer performance on the mentalizing condition compared to HCs.
Task-based PLS identified a significant latent variable separating mental from physical/random conditions differently in patients versus HCs.
Seed-based PLS revealed increased functional connectivity with the left inferior frontal gyrus (liFG) and caudate nucleus in schizophrenia patients, with liFG connectivity correlating with better mentalizing performance.

Conclusions:

Mentalizing deficits in schizophrenia may stem from inefficient social brain network functioning.
Aberrant functional connectivity in key social brain regions like the liFG and caudate nucleus is implicated in schizophrenia's social cognition impairments.