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Updated: Mar 12, 2026

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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
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ZIP restores estrogen receptor expression and response to Tamoxifen in estrogen receptor negative tumors
Ning Zhu1, Jing Zhang2, Xiaodong Qin2
1School of Life Science, Lanzhou University, Lanzhou, Gansu, 73000, PR China.
Biochemical and Biophysical Research Communications
|October 30, 2016
Abstract:
As a component of NURD histone deacetylase complex, ZIP serves as a tumor suppressor gene in the development of breast tumors. However, whether it takes part in chemotherapy resistance remains poorly defined. In the present study, we reported that ZIP enhanced the response to SERM chemotherapy in ER-negative cells. Overexpression of ZIP suppressed EGFR expression level and restored ERalpha protein level in cells resistant to Tamoxifen. In vivo data confirmed those in vitro findings.

