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Updated: Mar 12, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Breaking up sitting time after stroke (BUST-Stroke).

Heidi Janssen^1,2,3,4, David W Dunstan⁵, Julie Bernhardt^6,7

¹1 Hunter Stroke Service, Hunter New England Local Health District, Newcastle NSW, Australia.

International Journal of Stroke : Official Journal of the International Stroke Society

|October 30, 2016

Summary

This summary is machine-generated.

Breaking up prolonged sitting with walking or standing exercises may improve metabolic and cardiovascular health in stroke survivors. This study investigated the safety and feasibility of such interventions.

Keywords:

Sitting cardiovascular disease physical activity rehabilitation stroke stroke risk

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Area of Science:

Cardiovascular disease research
Metabolic health studies
Stroke rehabilitation science

Background:

Prolonged sitting increases mortality risk.
Effects of breaking up sitting time in stroke survivors are unknown.

Purpose of the Study:

To determine metabolic and cardiovascular effects of breaking up sitting time in stroke survivors.
To assess the safety and feasibility of intermittent activity breaks.

Main Methods:

Participants with stroke underwent three conditions: uninterrupted sitting, sitting with walking breaks, and sitting with standing breaks.
Blood samples and blood pressure were monitored over 8 hours.
Primary outcomes included postprandial glucose and insulin responses.

Main Results:

Activity breaks may attenuate negative effects of sitting on glucose and insulin metabolism.
Potential benefits for blood pressure, lipid profiles, and fibrinogen observed.
Protocol demonstrated safety and feasibility in stroke population.

Conclusions:

This study is a crucial first step in understanding the cardiovascular benefits of reducing sedentary time post-stroke.
Findings may inform strategies to lower recurrent stroke risk by modifying sitting behavior.