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Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems
R J R Blair1, K Veroude2, J K Buitelaar3
1Section on Affective Cognitive Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 15K, Room 206, Bethesda, MD, 20892, USA.
Abstract:
In this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent and its functional role/the symptom sets consequent on its dysfunction remain underspecified. However, dysfunctions in the other four neuro-cognitive systems are associated with symptom sets seen in individuals with conduct problems.
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