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Updated: Mar 12, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Place cells and long-term potentiation in the hippocampus
Luis Fernando Cobar1, Li Yuan1, Ayumu Tashiro1
1Warwick-NTU Neuroscience Programme, School of Biological Sciences, Nanyang Technological University, Singapore; Warwick-NTU Neuroscience Programme, School of Life Sciences, University of Warwick, UK.
Abstract:
Place cells show location-specific firing patterns according to an animal's position in an environment and are thought to contribute to the spatial representation required for self-navigation. Decades of study have extensively characterized the properties of place cells and suggested the involvement of long-term potentiation (LTP), a long-lasting synaptic strengthening, in place cell activity. Here, we review the basic characteristics of place cell activity and the findings that support the idea that LTP contributes to the formation, maintenance, and plasticity of place cell activity.
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