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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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ACE inhibitors, left ventricular mass and renal cyst growth in ADPKD

Robert W Schrier1

  • 1University of Colorado School of Medicine, University of Colorado Denver School of Medicine, Department of Medicine Division of Renal Diseases and Hypertension 12077 East 19th Avenue, C281 Research Building 2, Room 7001 Aurora, CO 80045, United States.

Pharmacological Research
|October 31, 2016
PubMed

Insights

Autosomal Dominant Polycystic Kidney Disease (ADPKD) involves cyst growth and hypertension. Angiotensin converting enzyme inhibition (ACEI) may treat these ADPKD symptoms by targeting the renin-angiotensin-aldosterone system (RAAS).

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic kidney disorder.
  • Renal cyst growth, hypertension, and left ventricular hypertrophy are key ADPKD complications.
  • The renin-angiotensin-aldosterone system (RAAS) is implicated in ADPKD pathogenesis.

Purpose of the Study:

  • To review the role of RAAS in ADPKD progression.
  • To evaluate the therapeutic potential of angiotensin converting enzyme inhibition (ACEI) in ADPKD.
  • To discuss ACEI effects beyond blood pressure control in ADPKD.

Main Methods:

  • Literature review of studies on ADPKD, RAAS, and ACEI.
  • Analysis of evidence linking RAAS to cyst growth and cardiovascular changes.
  • Examination of clinical data on ACEI efficacy in ADPKD patients.

Main Results:

  • RAAS activation is associated with increased renal cyst growth and hypertension in ADPKD.
  • ACEI demonstrates therapeutic benefits in reducing cyst volume and left ventricular mass.
  • ACEI offers advantages independent of blood pressure reduction in managing ADPKD.

Conclusions:

  • The RAAS plays a significant role in ADPKD pathogenesis.
  • ACEI is a promising therapeutic strategy for ADPKD, addressing multiple disease facets.
  • Further research into RAAS-targeted therapies for ADPKD is warranted.

Keywords:
EnalaprilKidneyRenin-angiotensin-aldosterone system

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