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Bronchiectasis and Aspergillus: How are they linked?

Anthony De Soyza1, Stefano Aliberti2

  • 1Institute of Cellular Medicine, Newcastle University NE2 4HH; and Adult Bronchiectasis Service, Department of Respiratory Medicine, Freeman Hospital, Heaton Road, Newcastle, NE7 7DN, UK anthony.de-soyza@ncl.ac.uk.

Medical Mycology
|October 31, 2016
PubMed
Summary
This summary is machine-generated.

Bronchiectasis, a growing lung condition, frequently co-occurs with Aspergillus infections. This review explores the diverse ways Aspergillus affects bronchiectasis patients and potential treatments.

Keywords:
AsthmaCOPDaspergillusbronchiectasisinvasive aspergillosis

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Area of Science:

  • Pulmonology and Infectious Diseases
  • Medical Mycology

Background:

  • Bronchiectasis is a chronic airway disease with increasing prevalence, linked to significant illness and death.
  • It arises from various causes, including infections and other lung conditions like COPD and severe asthma.
  • Bronchiectasis is notably associated with several Aspergillus-related conditions.

Purpose of the Study:

  • To discuss the pathogenesis of Aspergillus-associated diseases in patients with bronchiectasis.
  • To review the treatment strategies for these diverse fungal infections complicating bronchiectasis.

Main Methods:

  • Literature review focusing on the relationship between bronchiectasis and Aspergillus.
  • Analysis of pathogenesis and clinical presentations of various Aspergillus-associated syndromes in bronchiectasis.
  • Synthesis of current treatment approaches for these conditions.

Main Results:

  • Allergic bronchopulmonary aspergillosis (ABPA) can lead to or complicate bronchiectasis.
  • Aspergilloma and fungal bronchitis are observed in damaged lung tissue associated with bronchiectasis.
  • Invasive aspergillosis occurs in bronchiectasis patients, even without significant immunosuppression.

Conclusions:

  • Bronchiectasis presents a complex interplay with various Aspergillus infections.
  • Understanding the pathogenesis is crucial for managing these co-existing conditions.
  • Targeted treatment strategies are essential for improving outcomes in bronchiectasis patients with Aspergillus.