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RNAcentral: a comprehensive database of non-coding RNA sequences.

, Anton I Petrov, Simon J E Kay

    Nucleic Acids Research
    |October 31, 2016
    PubMed
    Summary

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    This summary is machine-generated.

    RNAcentral is a comprehensive database for non-coding RNA (ncRNA) sequences, integrating data from 22 specialized resources. It offers improved search functionalities and species-specific identifiers for all organisms.

    Area of Science:

    • Bioinformatics
    • Genomics
    • Molecular Biology

    Background:

    • RNAcentral aggregates non-coding RNA (ncRNA) sequence data from diverse specialized resources.
    • It serves as a unified access point for various ncRNA types across all organisms.

    Purpose of the Study:

    • To enhance RNAcentral by integrating more data resources and improving website functionalities.
    • To provide a comprehensive and accessible platform for ncRNA research.

    Main Methods:

    • Integration of data from 12 new specialized ncRNA resources, bringing the total to 22.
    • Inclusion of new data types, including modified nucleotides from MODOMICS and PDB.
    • Development of species-specific identifiers for unique RNA sequences within a species context.

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    Main Results:

    • RNAcentral now includes data from 22 collaborating databases.
    • New data types like modified nucleotides have been incorporated.
    • Enhanced website features include improved text and sequence similarity searches and genome browsing.

    Conclusions:

    • RNAcentral provides a continuously improving, free resource for accessing and analyzing ncRNA sequences.
    • The database facilitates ncRNA research through comprehensive data aggregation and advanced search capabilities.