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Physical Isolation of Endospores from Environmental Samples by Targeted Lysis of Vegetative Cells
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Physical Isolation of Endospores from Environmental Samples by Targeted Lysis of Vegetative Cells

Published on: January 21, 2016

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Inactivation Strategies for Clostridium perfringens Spores and Vegetative Cells

Prabhat K Talukdar1,2, Pathima Udompijitkul3, Ashfaque Hossain4

  • 1Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.

Applied and Environmental Microbiology
|November 1, 2016
PubMed

Insights

Clostridium perfringens spores are challenging to inactivate, posing risks to humans and animals. This review summarizes current strategies for controlling both C. perfringens spores and vegetative cells, highlighting their limitations.

Area of Science:

  • Microbiology
  • Food Safety
  • Veterinary Medicine

Background:

  • Clostridium perfringens is a significant pathogen causing various diseases in humans and animals.
  • C. perfringens spores are highly resistant and crucial for pathogenicity, surviving environmental dormancy.
  • Inactivating C. perfringens spores remains a significant challenge compared to vegetative cells.

Purpose of the Study:

  • To review and summarize inactivation strategies for Clostridium perfringens spores and vegetative cells.
  • To discuss the limitations and challenges associated with current control methods.
  • To provide insights into developing more effective inactivation approaches.

Main Methods:

  • Literature review of studies on C. perfringens inactivation strategies.
  • Categorization of methods into physical approaches, chemical preservatives, and natural antimicrobials.
  • Analysis of the efficacy and limitations of each strategy.

Main Results:

  • Various physical, chemical, and natural antimicrobial strategies exist for C. perfringens control.
  • Effective inactivation of vegetative cells is achievable, but spore inactivation is more difficult.
  • Current methods have limitations in terms of efficacy, safety, or practicality.

Conclusions:

  • Developing robust strategies for C. perfringens spore inactivation is critical for public and animal health.
  • Further research is needed to overcome the challenges associated with spore resistance.
  • A combination of approaches may be necessary for comprehensive control of C. perfringens.
Keywords:
Clostridium perfringensantimicrobial agentsfood poisoninginactivationsporesvegetative cells

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