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Marine-Derived Pharmaceuticals - Challenges and Opportunities
1Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, Greifswald D17489, Germany.
Biomolecules & Therapeutics
|November 1, 2016
Summary
Marine organisms produce unique compounds for survival, leading to FDA-approved drugs for cancer, viral diseases, and pain. Challenges in marine drug development include supply issues.
Area of Science:
- Marine Biology
- Pharmacology
- Drug Discovery
Background:
- The marine biosphere, Earth's largest ecosystem, hosts diverse organisms with unique survival adaptations.
- Marine organisms produce specialized secondary metabolites with significant biological activities.
Approach:
- This review synthesizes information on FDA-approved marine-derived pharmaceuticals.
- It details their sources, chemistry, production, and pharmacological applications.
- Arrangement is based on therapeutic indications.
Key Points:
- Four of seven approved marine drugs treat cancer.
- Other approved drugs target viral diseases, chronic pain, and high triglyceride levels.
- Marine compounds are also explored for diagnostics and research tools.
Conclusions:
- Marine-derived pharmaceuticals offer valuable therapeutic options.
- Drug development faces challenges, notably sustainable supply chain issues.
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