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Updated: Mar 12, 2026

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
Published on: January 11, 2019
Targeting apoptotic pathways to treat lymphoid malignancies
1Department of Clinical Hematology and Bone Marrow Transplantation, The Royal Melbourne Hospital.
Abstract:
Oncogenic transformation through activation of proliferation generates cellular stress which promotes apoptosis, thereby diminishing the growth advantage of cancerous cells over normal cells. Consequently, many haematological malignancies also harbour aberrations that circumvent apoptosis, with aberrations of TP53 and the BCL2 family being the most common. This educational lecture focuses on current understanding of the role of the intrinsic pathway to apoptosis in lymphoid cancers, its regulation by BCL2 and related proteins, and emerging data on the therapeutic potential of inhibiting BCL2 to induce apoptosis in BCL2-expressing B cell cancers.
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