Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

How does HTLV-1 induce ATL?

Masao Matsuoka¹

¹Institute for Virus Research, Kyoto University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology

|November 1, 2016

Summary

This summary is machine-generated.

Human T-cell leukemia virus type 1 (HTLV-1) promotes infected cell survival and proliferation, contributing to inflammation and diseases like adult T-cell leukemia (ATL). Understanding these viral strategies is key to combating HTLV-1 infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Azidothymidine potentiates the immunomodulatory function of interferon-α in adult T cell leukemia/lymphoma.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

HTLV-1 subverts the innate immune effector gene IRF7 by viral HBZ protein for oncogenesis.

Nature communications·2026

Same author

Intra-pol proviral open region of HTLV-1 controls the transcription from both long terminal repeats.

Retrovirology·2025

Same author

Peripheral Blood CD4/CD8 Ratio Predicts Out-of-Specification Products in Lisocabtagene Maraleucel Manufacturing.

Cancer reports (Hoboken, N.J.)·2025

Same author

Correction: Evolution of primate T-cell leukemia virus type 1 accessory genes and functional divergence of its antisense proteins.

PLoS pathogens·2025

Same author

Prognostic impact of valemetostat in relapsed/refractory adult T-cell leukaemia-lymphoma.

British journal of haematology·2025

Area of Science:

Virology
Immunology
Oncology

Background:

Human T-cell leukemia virus type 1 (HTLV-1) primarily infects CD4+ T cells.
HTLV-1 utilizes cell-to-cell transmission for in vivo spread.
Infected cells infiltrate tissues and transmit via bodily fluids like breast milk and semen.

Purpose of the Study:

To elucidate the mechanisms by which HTLV-1 promotes infected cell proliferation and immune evasion.
To understand the role of the HTLV-1 bZIP factor (HBZ) in viral pathogenesis.
To investigate the link between HTLV-1 infection, inflammation, and lymphomagenesis.

Main Methods:

The abstract does not specify methods.
The abstract does not specify methods.
The abstract does not specify methods.

More Related Videos

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Related Experiment Videos

Last Updated: Jan 10, 2026

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Main Results:

HTLV-1 viral genes facilitate infected cell proliferation and immune system evasion.
The HTLV-1 bZIP factor (HBZ) induces overproduction of interferon gamma.
Interferon gamma is associated with inflammation and the development of lymphoma.

Conclusions:

HTLV-1 employs strategies to enhance infected cell survival and proliferation.
These viral mechanisms are implicated in the induction of adult T-cell leukemia (ATL) and inflammatory diseases.
HBZ-induced interferon gamma contributes to HTLV-1 pathogenesis.