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Related Experiment Video

Updated: Mar 12, 2026

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
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Hepatic sarcoidosis: a case series.

Rym Ennaifer1, Shema Ayadi1, Hayfa Romdhane1

  • 1Department of Hepato-gastro-enterology, Mongi Slim Hospital, Tunis, Tunisia.

The Pan African Medical Journal
|November 1, 2016
PubMed
Summary

Systemic sarcoidosis commonly affects the liver, often presenting asymptomatically. Corticosteroids may be inadequate, highlighting the need for further research into treatments like ursodeoxycholic acid (UDCA) for liver sarcoidosis.

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Area of Science:

  • Hepatology
  • Immunology
  • Pulmonology

Background:

  • Sarcoidosis is a systemic granulomatous disease with frequent liver involvement.
  • Liver sarcoidosis is often asymptomatic, lacking established treatment guidelines.
  • Corticosteroid efficacy for liver sarcoidosis can be limited.

Purpose of the Study:

  • To describe the clinical, biochemical, radiological, and therapeutic features of systemic sarcoidosis with liver involvement.
  • To evaluate treatment outcomes in patients with liver sarcoidosis.

Main Methods:

  • Retrospective, descriptive, monocentric study over 3 years.
  • Inclusion of seven patients with confirmed systemic sarcoidosis and liver involvement.
  • Analysis of clinical data, liver function tests, liver biopsy, and treatment responses.
Keywords:
Sarcoidosischolestasiscorticosteroidsgranulomaliver

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Main Results:

  • All seven patients presented with hepatomegaly and abnormal liver function tests (anicteric cholestasis).
  • Liver biopsies revealed granulomatous lesions consistent with sarcoidosis; two patients had severe fibrosis.
  • Five patients received corticosteroids, two received ursodeoxycholic acid (UDCA); one showed steroid resistance, while antimalarials with UDCA were successful in a steroid-resistant case.

Conclusions:

  • Liver involvement can be an initial manifestation of systemic sarcoidosis and requires screening due to progression risk.
  • Current treatment relies on corticosteroids, but efficacy is variable, and UDCA's role needs further investigation.
  • More research, including randomized controlled trials, is needed to establish optimal treatment strategies for liver sarcoidosis.