Related Experiment Video

Updated: Mar 12, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

12.1K

[Clinical Manifestations in Autosomal Dominant Polycystic Kidney Disease (ADPKD)]

Giovanni Piscopo, Giovanna Capolongo

    Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
    |November 1, 2016
    PubMed

    Insights

    Autosomal dominant polycystic kidney disease (ADPKD) is a systemic condition with significant extrarenal issues like polycystic liver disease. Early recognition and management of ADPKD complications are crucial for patient outcomes.

    Area of Science:

    • Nephrology
    • Genetics
    • Systemic Diseases

    Background:

    • Autosomal dominant polycystic kidney disease (ADPKD) is a systemic genetic disorder.
    • ADPKD presents with numerous extrarenal manifestations, impacting quality of life and disease burden.
    • Key extrarenal manifestations include polycystic liver disease (PCLD), gastrointestinal issues, pancreatic cysts, hernias, and diverticular disease.

    Purpose of the Study:

    • To highlight the significant role of extrarenal manifestations in ADPKD.
    • To emphasize the importance of early diagnosis and prevention of ADPKD-related complications.
    • To inform nephrologists about recognizing and managing diverse clinical manifestations of ADPKD.

    Main Methods:

    • Review of clinical manifestations and natural history of ADPKD.
    • Analysis of factors influencing renal function decline.
    • Discussion of nephrologist's role in managing systemic ADPKD.

    Main Results:

    • ADPKD involves a long stable period followed by progressive renal function decline.
    • Hypertension, cyst infections, and nephrolithiasis accelerate kidney failure.
    • Extrarenal conditions like PCLD and hernias significantly contribute to disease burden.

    Conclusions:

    • Early diagnosis and prevention of ADPKD complications, including extrarenal manifestations, are fundamental.
    • Nephrologists must be adept at recognizing and managing diverse ADPKD-related conditions.
    • Comprehensive management addressing both renal and extrarenal aspects is vital for ADPKD patients.

    More Related Videos

    Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

    Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

    Published on: September 1, 2015

    10.3K
    Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay08:13

    Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

    Published on: February 20, 2015

    14.0K

    Related Concept Videos

    Chronic Kidney Disease II: Clinical Manifestations01:24

    Chronic Kidney Disease II: Clinical Manifestations

    Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
    870
    Chronic Kidney Disease I: Introduction01:25

    Chronic Kidney Disease I: Introduction

    Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
    936
    Nephrons01:10

    Nephrons

    The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
    8.1K
    Nephrotic Syndrome I : Introduction01:24

    Nephrotic Syndrome I : Introduction

    Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
    807
    Renal Corpuscle01:20

    Renal Corpuscle

    The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
    Glomerulus: Structure and Function
    The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
    8.2K
    Cystic Fibrosis: Pathogenesis01:23

    Cystic Fibrosis: Pathogenesis

    Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
    CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
    994