Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.9K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.9K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

1.2K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.2K
Amyloid Fibrils03:03

Amyloid Fibrils

12.5K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.5K
Neural Regulation01:37

Neural Regulation

44.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan.

NMR in biomedicine·2026
Same author

Quantifying Skin Sodium Concentration With Novel Very Rapid Biexponential T<sub>2</sub> Relaxometry and Signal Loss Compensation Methodology.

Magnetic resonance in medicine·2026
Same author

Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan.

NMR in biomedicine·2026
Same author

Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.

NMR in biomedicine·2026
Same author

Narrative coherence shapes functional connectivity in default mode and frontoparietal networks.

Neuroimage. Reports·2026
Same author

Correction: Data-driven disease subgrouping in ALS: a multicenter cerebral functional connectivity study.

Journal of neurology·2026

Related Experiment Video

Updated: Mar 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.4K

White matter structural network abnormalities underlie executive dysfunction in amyotrophic lateral sclerosis.

Dennis Dimond1, Abdullah Ishaque1, Sneha Chenji1

  • 1Neuroscience and Mental Health Institute, University of Alberta, 4-142 Katz Group Centre, 116 St. and 85 Ave, Edmonton, Alberta, T6G 2E1, Canada.

Human Brain Mapping
|November 1, 2016
PubMed
Summary

Executive dysfunction in amyotrophic lateral sclerosis (ALS) is linked to disrupted frontal lobe connectivity and white matter integrity. Cognitive impairment in ALS patients stems from these brain network abnormalities.

Keywords:
amyotrophic lateral sclerosisexecutive functiongraph theorymotor neuron diseasestructural connectivitytract-based spatial statisticswhite matter integrity

More Related Videos

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.3K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K

Related Experiment Videos

Last Updated: Mar 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.4K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.3K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Executive dysfunction is common in amyotrophic lateral sclerosis (ALS).
  • This cognitive deficit is associated with altered brain structure and connectivity.
  • Understanding these changes is crucial for managing ALS cognitive impairment.

Purpose of the Study:

  • To investigate the white matter basis of executive dysfunction in ALS.
  • To identify structural brain abnormalities in cognitively impaired ALS patients.
  • To correlate executive function with white matter integrity and network properties.

Main Methods:

  • Magnetic resonance imaging (MRI) on a 4.7 Tesla scanner.
  • Neuropsychometric testing for cognitive assessment.
  • Tract-based spatial statistics and connectomics analysis.

Main Results:

  • Executive function correlated with white matter fractional anisotropy (FA) and network metrics, particularly in the frontal lobe.
  • Cognitively impaired ALS patients showed altered local connectivity and white matter integrity in frontal regions.
  • These frontal alterations correlated with executive dysfunction severity.

Conclusions:

  • Executive dysfunction in ALS is associated with frontal and global network disconnectivity.
  • Diminished white matter integrity underlies these network disruptions.
  • Frontal network disconnectivity may mediate cognitive impairment in ALS.