Estimating 10-year cardiovascular disease risk in Asian patients with schizophrenia

This study aims to describe the cardiovascular risk profile of Asian patients with schizophrenia.

Data was extracted from the databases of 139 patients with schizophrenia and 206 controls from two previous studies conducted at the Institute for Mental Health (IMH), Singapore. Their medical and smoking histories were obtained, and anthropometric parameters measured. Framingham risk score (FRS) calculator using body mass index was used to compute the 10-year cardiovascular disease risk (FRS_BMI) and the vascular age (VA_BMI) for each participant. Data on fasting lipids were available for 80 patients and all the controls; hence the FRS for lipids (FRS_lipids) and VA (VA_lipids) were also computed. The difference between VA and actual age was computed as VA_diff.

The 10-year CVD risk and VA_diff based on lipids as well as BMI were significantly higher for patients compared to controls (all p<0.01). There was a strong correlation between FRS_lipids and FRS_BMI (r=0.97, p<0.001). Significantly higher numbers of patients than controls were smokers and obese; and reported having dyslipidaemia.

We found a high risk of CVD in patients with schizophrenia as compared to controls; and conclude that patients with schizophrenia need regular physical health monitoring, especially for cardiovascular risk factors.